Fabry Disease Market Size was valued at USD 2.1 billion in 2022 and is projected to grow from USD 2.26 Billion in 2023 to USD 4.12 billion by 2032, exhibiting a compound annual growth rate (CAGR) of 7.8% during the forecast period (2023 – 2032).

Fabry disease, a rare genetic disorder, affects the body’s ability to break down a specific fatty substance. This disorder can lead to severe health issues, including kidney failure, heart problems, and stroke. The Fabry disease market is currently experiencing significant growth due to increased awareness, improved diagnostic techniques, and the development of novel therapies.

The market is driven by several factors, including advancements in genetic research and the introduction of enzyme replacement therapies (ERTs). ERTs, such as agalsidase beta, have become the cornerstone of Fabry disease treatment, significantly improving patient outcomes. Additionally, the emergence of chaperone therapies and gene therapies is expected to further propel market growth.

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Market Segmentation

The Fabry Disease Market is a specialized sector within the healthcare industry, focusing on the diagnosis, treatment, and management of Fabry disease. This rare genetic disorder, characterized by a deficiency in the enzyme alpha-galactosidase A, leads to the accumulation of globotriaosylceramide (Gb3) in various body tissues, causing a range of symptoms including pain, kidney dysfunction, heart issues, and strokes.

Market segmentation for the Fabry Disease Market is primarily based on treatment types, including enzyme replacement therapy (ERT), chaperone therapy, and substrate reduction therapy (SRT). ERT currently dominates the market due to its efficacy in replacing the deficient enzyme. However, innovations in chaperone therapy and SRT are gaining traction, offering alternative options for patients who may not respond well to ERT.

Competitive Landscape

Amgen Inc., Amicus Therapeutics Inc., Bristol-Myers Squibb Company, GlaxoSmithKline, iBio,  Neuraltus Pharmaceuticals, Novartis AG, Pfizer Inc., AVROBIO, Idorsia Pharmaceuticals Ltd, Protalix, Sanofi, Shire, Takeda Pharmaceutical Company Limited, and Teva Pharmaceutical Industries Ltd.

Regional Analysis

Geographically, the Americas is expected to dominate the global market owing to the increasing technological advancements and rising research and development activities. Gastrointestinal manifestations such as abdominal pain, diarrhea and nausea are significant burden in a patient with Fabry disease. So, for the advanced treatment of these patients SmartPill testing procedure is developed to gain additional understanding of Fabry disease manifestation via motility abnormalities in order to improve symptom targeted therapy. This device is currently under clinical trial and the sponsor of this study is Massachusetts General Hospital.

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Europe is expected to hold the second largest market share. Nearly 2.2 in 10,000 people in the European Union (EU) are affected with Fabry disease and Fabrazyme (agalsidase beta), Galafold (migalastat) and Replagal (agalsidase alfa) are the three authorized drugs used for the treatment of Fabry disease.

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Asia-Pacific is expected to be the fastest growing market owing to the improving healthcare infrastructure.

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